CATH Domain 4kjdA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.720	Alkaline Phosphatase, subunit A
	3.40.720.10	Alkaline Phosphatase, subunit A

Domain Context

CATH Clusters

Superfamily	Alkaline Phosphatase, subunit A
Functional Family	Alkaline phosphatase

Enzyme Information

3.1.3.1

Alkaline phosphatase.

based on mapping to UniProt P15693

A phosphate monoester + H(2)O = an alcohol + phosphate.

-!- Active at a high pH optimum. -!- Wide specificity. -!- Also catalyzes transphosphorylations. -!- Some enzymes hydrolyze diphosphate (cf. EC 3.6.1.1).

UniProtKB Entries (1)

P15693

PPBI1_RAT

Rattus norvegicus

Intestinal-type alkaline phosphatase 1

PDB Structure

PDB	4KJD
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of rat intestinal alkaline phosphatase - Role of crown domain in mammalian alkaline phosphatases. Ghosh, K., Mazumder Tagore, D., Anumula, R., Lakshmaiah, B., Kumar, P.P., Singaram, S., Matan, T., Kallipatti, S., Selvam, S., Krishnamurthy, P., Ramarao, M. J.Struct.Biol.