CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Mitogen-activated protein kinase 14

Enzyme Information
Mitogen-activated protein kinase.
based on mapping to UniProt Q16539
ATP + a protein = ADP + a phosphoprotein.
-!- Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC is necessary for enzyme activation. -!- Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline. -!- A distinguishing feature of all MAPKs is the conserved sequence Thr- Xaa-Tyr (TXY). -!- Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. -!- Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury. -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
Mitogen-activated protein kinase 14

PDB Structure

External Links
Primary Citation
The Identification of Novel P38-Alpha Isoform Selective Kinase Inhibitors Having an Unprecedented P38-Alpha Binding Mode
Wrobleski, S.T., Lin, S., Murali Dhar, T.G., Dyckman, A.J., Li, T., Pitt, S., Zhang, R., Fan, Y., Doweyko, A.M., Tokarski, J.S., Kish, K.F., Kiefer, S.E., Sack, J.S., Newitt, J.A., Witmer, M.R., McKinnon, M., Barrish, J.C., Dodd, J.H., Schieven, G.L., Leftheris, K.