CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.20 | Up-down Bundle | |
1.20.1270 | Substrate Binding Domain Of Dnak; Chain:A; Domain 2 | |
1.20.1270.250 |
Domain Context
CATH Clusters
Superfamily | 1.20.1270.250 |
Functional Family | Putative inhibitor of nuclear factor kappa-B kinase subunit beta |
Enzyme Information
2.7.11.10 |
I-kappa-B kinase.
based on mapping to UniProt O14920
ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].
-!- Phosphorylates I-kappa-B proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway. -!- Subsequent degradation of the I-kappa-B complex (IKK) activates NF-kappa-B, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis. -!- If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably. -!- Formerly EC 2.7.1.37.
|
UniProtKB Entries (1)
O14920 |
IKKB_HUMAN
Homo sapiens
Inhibitor of nuclear factor kappa-B kinase subunit beta
|
PDB Structure
PDB | 4KIK |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal Structure of a Human I kappa B Kinase beta Asymmetric Dimer.
J.Biol.Chem.
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