CATH Domain 4khmA03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.70	Alpha-Beta Plaits
	3.30.70.270	Reverse transcriptase/Diguanylate cyclase domain

Domain Context

CATH Clusters

Superfamily	3.30.70.270
Functional Family	Genome polyprotein

Enzyme Information

UniProtKB Entries (1)

B1PPP0_9HEPC

Hepatitis C virus subtype 1a

Genome polyprotein

PDB Structure

PDB	4KHM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase. Maynard, A., Crosby, R.M., Ellis, B., Hamatake, R., Hong, Z., Johns, B.A., Kahler, K.M., Koble, C., Leivers, A., Leivers, M.R., Mathis, A., Peat, A.J., Pouliot, J.J., Roberts, C.D., Samano, V., Schmidt, R.M., Smith, G.K., Spaltenstein, A., Stewart, E.L., Thommes, P., Turner, E.M., Voitenleitner, C., Walker, J.T., Waitt, G., Weatherhead, J., Weaver, K., Williams, S., Wright, L., Xiong, Z.Z., Haigh, D., Shotwell, J.B. J.Med.Chem.