CATH Domain 4kfeA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.450	Nuclear Transport Factor 2; Chain: A,
	3.10.450.40

Domain Context

CATH Clusters

Superfamily	3.10.450.40
Functional Family

Enzyme Information

1.4.3.21

Primary-amine oxidase.

based on mapping to UniProt P12807

RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).

-!- A group of enzymes that oxidize primary monoamines but have little or no activity toward diamines, such as histamine, or toward secondary and tertiary amines. -!- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. -!- In some mammalian tissues the enzyme also functions as a vascular- adhesion protein (VAP-1). -!- Formerly EC 1.4.3.6.

UniProtKB Entries (1)

P12807

AMO_PICAN

Ogataea angusta

Peroxisomal primary amine oxidase

PDB Structure

PDB	4KFE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural evidence for the semiquinone in a copper amine oxidase from Hansenula polymorpha: implications for the catalytic mechanism Johnson, B.J., Yukl, E.T., Klema, V.J., Klinman, J.P., Wilmot, C.M. J.Biol.Chem.