CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.10 | Roll |
|
3.10.330 | Vcp-like ATPase; Chain A, domain 2 |
|
3.10.330.10 |
Domain Context
CATH Clusters
| Superfamily | 3.10.330.10 |
| Functional Family | Cell division control 48 |
Enzyme Information
| 3.6.4.6 |
Vesicle-fusing ATPase.
based on mapping to UniProt P55072
ATP + H(2)O = ADP + phosphate.
-!- A large family of ATP-hydrolyzing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. -!- They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. -!- They include peroxin, which apparently is involved in Zellweger's syndrome.
|
UniProtKB Entries (2)
| P55072 |
TERA_HUMAN
Homo sapiens
Transitional endoplasmic reticulum ATPase
|
| P43558 |
OTU1_YEAST
Saccharomyces cerevisiae S288C
Ubiquitin thioesterase OTU1
|
PDB Structure
| PDB | 4KDI |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Basis for Ovarian Tumor Domain-containing Protein 1 (OTU1) Binding to p97/Valosin-containing Protein (VCP).
J.Biol.Chem.
|
