CATH Classification
Level | CATH Code | Description |
---|---|---|
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1 | Mainly Alpha |
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1.10 | Orthogonal Bundle |
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1.10.1410 | Poly(a)-polymerase, middle domain |
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1.10.1410.40 |
Domain Context
CATH Clusters
Superfamily | 1.10.1410.40 |
Functional Family | Cyclic GMP-AMP synthase |
Enzyme Information
2.7.7.86 |
Cyclic GMP-AMP synthase.
based on mapping to UniProt Q8C6L5
ATP + GTP = 2 diphosphate + cyclic G-P(2'-5')A-P(3'-5').
-!- Cyclic Gp(2'-5')Ap(3'-5') is a signaling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.
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UniProtKB Entries (1)
Q8C6L5 |
CGAS_MOUSE
Mus musculus
Cyclic GMP-AMP synthase
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PDB Structure
PDB | 4K8V |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Cell(Cambridge,Mass.)
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