CATH Domain 4k77A02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Tyrosine-protein kinase JAK2

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P23458

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P23458

JAK1_HUMAN

Homo sapiens

Tyrosine-protein kinase JAK1

PDB Structure

PDB	4K77
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors. Labadie, S., Barrett, K., Blair, W.S., Chang, C., Deshmukh, G., Eigenbrot, C., Gibbons, P., Johnson, A., Kenny, J.R., Kohli, P.B., Liimatta, M., Lupardus, P.J., Shia, S., Steffek, M., Ubhayakar, S., Abbema, A.V., Zak, M. Bioorg.Med.Chem.Lett.