CATH Domain 4jzfH02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.21

Coagulation factor VIIa.

based on mapping to UniProt P08709

Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.

-!- Formed from the precursor factor VII. -!- The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P08709

FA7_HUMAN

Homo sapiens

Coagulation factor VII

PDB Structure

PDB	4JZF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of nonbenzamidine factor VIIa inhibitors using a biaryl acid scaffold. Bolton, S.A., Sutton, J.C., Anumula, R., Bisacchi, G.S., Jacobson, B., Slusarchyk, W.A., Treuner, U.D., Wu, S.C., Zhao, G., Pi, Z., Sheriff, S., Smirk, R.A., Bisaha, S., Cheney, D.L., Wei, A., Schumacher, W.A., Hartl, K.S., Liu, E., Zahler, R., Seiler, S.M. Bioorg.Med.Chem.Lett.