CATH Domain 4jwjA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1280	Alpha/beta knot
	3.40.1280.30

Domain Context

CATH Clusters

Superfamily	3.40.1280.30
Functional Family	tRNA (guanine(9)-N1)-methyltransferase

Enzyme Information

2.1.1.221

tRNA (guanine(9)-N(1))-methyltransferase.

based on mapping to UniProt Q12400

S-adenosyl-L-methionine + guanine(9) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(9) in tRNA.

-!- The enzyme from Saccharomyces cerevisiae specifically methylates guanine(9). -!- The bifunctional enzyme from Thermococcus kodakaraensis also catalyzes the methylation of adenine(9) in tRNA (cf. EC 2.1.1.218). -!- Formerly EC 2.1.1.31.

UniProtKB Entries (1)

Q12400

TRM10_YEAST

Saccharomyces cerevisiae S288C

TRNA (guanine(9)-N1)-methyltransferase

PDB Structure

PDB	4JWJ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate. Shao, Z., Yan, W., Peng, J., Zuo, X., Zou, Y., Li, F., Gong, D., Ma, R., Wu, J., Shi, Y., Zhang, Z., Teng, M., Li, X., Gong, Q. Nucleic Acids Res.