CATH Domain 4jwhA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1280	Alpha/beta knot
	3.40.1280.30

Domain Context

CATH Clusters

Superfamily	3.40.1280.30
Functional Family	tRNA methyltransferase 10 homolog A

Enzyme Information

2.1.1.221

tRNA (guanine(9)-N(1))-methyltransferase.

based on mapping to UniProt O14214

S-adenosyl-L-methionine + guanine(9) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(9) in tRNA.

-!- The enzyme from Saccharomyces cerevisiae specifically methylates guanine(9). -!- The bifunctional enzyme from Thermococcus kodakaraensis also catalyzes the methylation of adenine(9) in tRNA (cf. EC 2.1.1.218). -!- Formerly EC 2.1.1.31.

UniProtKB Entries (1)

O14214

TRM10_SCHPO

Schizosaccharomyces pombe 972h-

TRNA (guanine(9)-N1)-methyltransferase

PDB Structure

PDB	4JWH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate. Shao, Z., Yan, W., Peng, J., Zuo, X., Zou, Y., Li, F., Gong, D., Ma, R., Wu, J., Shi, Y., Zhang, Z., Teng, M., Li, X., Gong, Q. Nucleic Acids Res.