CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.1280 | Alpha/beta knot |
|
3.40.1280.30 |
Domain Context
CATH Clusters
| Superfamily | 3.40.1280.30 |
| Functional Family | tRNA methyltransferase 10 homolog A |
Enzyme Information
| 2.1.1.221 |
tRNA (guanine(9)-N(1))-methyltransferase.
based on mapping to UniProt O14214
S-adenosyl-L-methionine + guanine(9) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(9) in tRNA.
-!- The enzyme from Saccharomyces cerevisiae specifically methylates guanine(9). -!- The bifunctional enzyme from Thermococcus kodakaraensis also catalyzes the methylation of adenine(9) in tRNA (cf. EC 2.1.1.218). -!- Formerly EC 2.1.1.31.
|
UniProtKB Entries (1)
| O14214 |
TRM10_SCHPO
Schizosaccharomyces pombe 972h-
TRNA (guanine(9)-N1)-methyltransferase
|
PDB Structure
| PDB | 4JWH |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate.
Nucleic Acids Res.
|