CATH Domain 4jr5A02

Superfamily	Aldolase class I
Functional Family

2.4.2.12

Nicotinamide phosphoribosyltransferase.

based on mapping to UniProt P43490

Nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho- alpha-D-ribose 1-diphosphate.

NAMPT_HUMAN

Homo sapiens

Nicotinamide phosphoribosyltransferase

PDB	4JR5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (nampt) inhibitors. Zheng, X., Bauer, P., Baumeister, T., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Han, B., Ho, Y.C., Kley, N., Lin, J., Reynolds, D.J., Sharma, G., Smith, C.C., Wang, Z., Dragovich, P.S., Oh, A., Wang, W., Zak, M., Gunzner-Toste, J., Zhao, G., Yuen, P.W., Bair, K.W. J.Med.Chem.