CATH Domain 4jnbA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.190	Protein-Tyrosine Phosphatase; Chain A
	3.90.190.10	Protein tyrosine phosphatase superfamily

Domain Context

CATH Clusters

Superfamily	Protein tyrosine phosphatase superfamily
Functional Family	Dual specificity phosphatase 12

Enzyme Information

3.1.3.16

Protein-serine/threonine phosphatase.

based on mapping to UniProt Q9UNI6

[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.

-!- A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48). -!- The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).

3.1.3.48

Protein-tyrosine-phosphatase.

based on mapping to UniProt Q9UNI6

Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.

-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

Q9UNI6

DUS12_HUMAN

Homo sapiens

Dual specificity protein phosphatase 12

PDB Structure

PDB	4JNB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The family-wide structure and function of human dual-specificity protein phosphatases. Jeong, D.G., Wei, C.H., Ku, B., Jeon, T.J., Chien, P.N., Kim, J.K., Park, S.Y., Hwang, H.S., Ryu, S.Y., Park, H., Kim, D.S., Kim, S.J., Ryu, S.E. Acta Crystallogr.,Sect.D