CATH Domain 4jkxA02

CATH Classification

Level	CATH Code	Description
	4	Few Secondary Structures
	4.10	Irregular
	4.10.470	Ricin (A Subunit), domain 2
	4.10.470.10	Ricin (A Subunit), domain 2

Domain Context

CATH Clusters

Superfamily	Ricin (A Subunit), domain 2
Functional Family

Enzyme Information

3.2.2.22

rRNA N-glycosylase.

based on mapping to UniProt P81446

Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.

-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P81446

ML1_VISAL

Viscum album

Beta-galactoside-specific lectin 1

PDB Structure

PDB	4JKX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure Mistletoe Lectin I from Viscum album in complex with kinetin at 2.35 A resolution. Prokofev, I.I., Lashkov, A.A., Gabdoulkhakov, A.G., Meyer, A., Barciszewski, J., Betzel, C., Mikhailov, A.M. To be Published