CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.420 | Nucleotidyltransferase; domain 5 | |
3.30.420.230 | Prp8 RNase H domain, palm region |
Domain Context
CATH Clusters
Superfamily | 3.30.420.230 |
Functional Family | Pre-mRNA-processing-splicing factor 8 |
Enzyme Information
UniProtKB Entries (1)
Q6P2Q9 |
PRP8_HUMAN
Homo sapiens
Pre-mRNA-processing-splicing factor 8
|
PDB Structure
PDB | 4JKF |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation.
Nat.Struct.Mol.Biol.
|