CATH Domain 4jkeA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.80	Acyl-CoA Binding Protein
	1.20.80.40	Prp8 RNase H domain, fingers region

Domain Context

CATH Clusters

Superfamily	1.20.80.40
Functional Family

Enzyme Information

UniProtKB Entries (1)

PRP8_HUMAN

Homo sapiens

Pre-mRNA-processing-splicing factor 8

PDB Structure

PDB	4JKE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Schellenberg, M.J., Wu, T., Ritchie, D.B., Fica, S., Staley, J.P., Atta, K.A., Lapointe, P., Macmillan, A.M. Nat.Struct.Mol.Biol.