CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.420 | Nucleotidyltransferase; domain 5 |
|
3.30.420.230 | Prp8 RNase H domain, palm region |
Domain Context
CATH Clusters
| Superfamily | 3.30.420.230 |
| Functional Family | Pre-mRNA-processing-splicing factor 8 |
Enzyme Information
UniProtKB Entries (1)
| Q6P2Q9 |
PRP8_HUMAN
Homo sapiens
Pre-mRNA-processing-splicing factor 8
|
PDB Structure
| PDB | 4JKE |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation.
Nat.Struct.Mol.Biol.
|
