CATH Domain 4jibA00

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1300	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
	1.10.1300.10	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Superfamily	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family	Phosphodiesterase

3.1.4.17

3',5'-cyclic-nucleotide phosphodiesterase.

based on mapping to UniProt O00408

Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.

-!- Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.

PDE2A_HUMAN

Homo sapiens

CGMP-dependent 3',5'-cyclic phosphodiesterase

PDB	4JIB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, Part I: Transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors. Plummer, M.S., Cornicelli, J., Roark, H., Skalitzky, D.J., Stankovic, C.J., Bove, S., Pandit, J., Goodman, A., Hicks, J., Shahripour, A., Beidler, D., Lu, X.K., Sanchez, B., Whitehead, C., Sarver, R., Braden, T., Gowan, R., Shen, X.Q., Welch, K., Ogden, A., Sadagopan, N., Baum, H., Miller, H., Banotai, C., Spessard, C., Lightle, S. Bioorg.Med.Chem.Lett.