CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.420 | Nucleotidyltransferase; domain 5 |
|
3.30.420.540 |
Domain Context
CATH Clusters
| Superfamily | 3.30.420.540 |
| Functional Family |
Enzyme Information
| 3.6.1.15 |
Nucleoside-triphosphate phosphatase.
based on mapping to UniProt Q27895
NTP + H(2)O = NDP + phosphate.
-!- The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. -!- Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD. -!- The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
|
UniProtKB Entries (1)
| Q27895 |
NTP2_TOXGO
Toxoplasma gondii
Nucleoside-triphosphatase 2
|
PDB Structure
| PDB | 4JEP |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The crystal structure of Toxoplasma gondii nucleoside triphosphate diphosphohydrolase 1 represents a conformational intermediate in the reductive activation mechanism of the tetrameric enzyme.
Proteins
|
