CATH Domain 4ja8A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.718	Isopropylmalate Dehydrogenase
	3.40.718.10	Isopropylmalate Dehydrogenase

Domain Context

CATH Clusters

Superfamily	Isopropylmalate Dehydrogenase
Functional Family	Isocitrate dehydrogenase [NADP]

Enzyme Information

1.1.1.42

Isocitrate dehydrogenase (NADP(+)).

based on mapping to UniProt P48735

Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.

-!- Unlike EC 1.1.1.41, oxalosuccinate can be used as a substrate. -!- In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD(+)-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP(+)-linked enzyme that is found in both mitochondria and cytoplasm. -!- The enzyme from some species can also use NAD(+) but much more slowly.

UniProtKB Entries (1)

P48735

IDHP_HUMAN

Homo sapiens

Isocitrate dehydrogenase [NADP], mitochondrial

PDB Structure

PDB	4JA8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Wang, F., Travins, J., DeLaBarre, B., Penard-Lacronique, V., Schalm, S., Hansen, E., Straley, K., Kernytsky, A., Liu, W., Gliser, C., Yang, H., Gross, S., Artin, E., Saada, V., Mylonas, E., Quivoron, C., Popovici-Muller, J., Saunders, J.O., Salituro, F.G., Yan, S., Murray, S., Wei, W., Gao, Y., Dang, L., Dorsch, M., Agresta, S., Schenkein, D.P., Biller, S.A., Su, S.M., de Botton, S., Yen, K.E. Science