CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.70 | Distorted Sandwich |
|
2.70.98 | Beta-galactosidase; Chain A, domain 5 |
|
2.70.98.110 | Glycosyl hydrolase family 63, N-terminal domain |
Domain Context
CATH Clusters
| Superfamily | Glycosyl hydrolase family 63, N-terminal domain |
| Functional Family |
Enzyme Information
| 3.2.1.106 |
Mannosyl-oligosaccharide glucosidase.
based on mapping to UniProt P53008
Glc(3)Man(9)GlcNAc(2)-[protein] + H(2)O = Glc(2)Man(9)GlcNAc(2)-[protein] + beta-D-glucopyranose.
-!- This enzyme catalyzes the first step in the processing of the N-glycan tetradecasaccharide precursor Glc(3)Man(9)GlcNAc(2), which takes place in the endoplasmic reticulum, by removing the distal alpha-1,2-linked glucose residue. -!- This and subsequent processing steps are required before complex N-glycans can be synthesized.
|
UniProtKB Entries (1)
| P53008 |
CWH41_YEAST
Saccharomyces cerevisiae S288C
Mannosyl-oligosaccharide glucosidase
|
PDB Structure
| PDB | 4J5T |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Specificity of processing alpha-glucosidase I is guided by the substrate conformation: crystallographic and in silico studies.
J.Biol.Chem.
|
