CATH Domain 4j2eA06

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1820	Ribonuclease H-like motif
	3.40.1820.10	DnaQ-like 3'-5' exonuclease

Domain Context

CATH Clusters

Superfamily	DnaQ-like 3'-5' exonuclease
Functional Family	DNA-directed DNA polymerase

Enzyme Information

2.7.7.7	DNA-directed DNA polymerase. based on mapping to UniProt Q38087 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
3.1.11.-	Exodeoxyribonucleases producing 5'-phosphomonoesters. based on mapping to UniProt Q38087

UniProtKB Entries (1)

DPOL_BPR69

Enterobacteria phage RB69

DNA-directed DNA polymerase

PDB Structure

PDB	4J2E
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Alteration in the cavity size adjacent to the active site of RB69 DNA polymerase changes its conformational dynamics. Xia, S., Wood, M., Bradley, M.J., De La Cruz, E.M., Konigsberg, W.H. Nucleic Acids Res.