CATH Domain 4j23B00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.80	Trefoil
	2.80.10	Trefoil (Acidic Fibroblast Growth Factor, subunit A)
	2.80.10.50

Domain Context

CATH Clusters

Superfamily	2.80.10.50
Functional Family	Fibroblast growth factor 1

Enzyme Information

UniProtKB Entries (1)

FGFR2_HUMAN

Homo sapiens

Fibroblast growth factor receptor 2

PDB Structure

PDB	4J23
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling. Herbert, C., Schieborr, U., Saxena, K., Juraszek, J., De Smet, F., Alcouffe, C., Bianciotto, M., Saladino, G., Sibrac, D., Kudlinzki, D., Sreeramulu, S., Brown, A., Rigon, P., Herault, J.P., Lassalle, G., Blundell, T.L., Rousseau, F., Gils, A., Schymkowitz, J., Tompa, P., Herbert, J.M., Carmeliet, P., Gervasio, F.L., Schwalbe, H., Bono, F. Cancer Cell