CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Hepatocyte growth factor receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P08581
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P08581
MET_HUMAN
Homo sapiens
Hepatocyte growth factor receptor

PDB Structure

PDB 4IWD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met.
Northrup, A.B., Katcher, M.H., Altman, M.D., Chenard, M., Daniels, M.H., Deshmukh, S.V., Falcone, D., Guerin, D.J., Hatch, H., Li, C., Lu, W., Lutterbach, B., Allison, T.J., Patel, S.B., Reilly, J.F., Reutershan, M., Rickert, K.W., Rosenstein, C., Soisson, S.M., Szewczak, A.A., Walker, D., Wilson, K., Young, J.R., Pan, B.S., Dinsmore, C.J.
J.Med.Chem.