CATH Domain 4iriA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.10	Arc Repressor Mutant, subunit A
	1.10.10.10	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Domain Context

CATH Clusters

Superfamily	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Functional Family	Friend leukemia integration 1 transcription factor

Enzyme Information

UniProtKB Entries (1)

ERG_HUMAN

Homo sapiens

Transcriptional regulator ERG

PDB Structure

PDB	4IRI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural and dynamic studies of the transcription factor ERG reveal DNA binding is allosterically autoinhibited. Regan, M.C., Horanyi, P.S., Pryor, E.E., Sarver, J.L., Cafiso, D.S., Bushweller, J.H. Proc.Natl.Acad.Sci.USA