CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.470 | Uracil-DNA Glycosylase, subunit E |
|
3.40.470.10 | Uracil-DNA glycosylase-like domain |
Domain Context
CATH Clusters
| Superfamily | Uracil-DNA glycosylase-like domain |
| Functional Family |
Enzyme Information
| 3.2.2.27 |
Uracil-DNA glycosylase.
based on mapping to UniProt P04303
Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.
-!- Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms. -!- Uracil-DNA glycosylase (EC 3.2.2.27) and double-stranded uracil-DNA glycosylase (EC 3.2.2.28) form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolyzing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalyzing the removal of mis-incorporated uracil from DNA.
|
UniProtKB Entries (1)
| P04303 |
UNG_VACCW
Vaccinia virus WR
Uracil-DNA glycosylase
|
PDB Structure
| PDB | 4IRB |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Mutations at the dimer interface affect both function and structure of the Vaccinia virus uracil DNA glycosylase
To be Published
|