CATH Domain 4iqwA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.150	DNA polymerase; domain 1
	1.10.150.20	5' to 3' exonuclease, C-terminal subdomain

Domain Context

CATH Clusters

Superfamily	5' to 3' exonuclease, C-terminal subdomain
Functional Family	DNA polymerase lambda

Enzyme Information

3.1.11.-	Exodeoxyribonucleases producing 5'-phosphomonoesters. based on mapping to UniProt P09838
2.7.7.31	DNA nucleotidylexotransferase. based on mapping to UniProt P09838 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes template-independent extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Nucleoside may be ribo- or deoxyribo-.

UniProtKB Entries (1)

TDT_MOUSE

Mus musculus

DNA nucleotidylexotransferase

PDB Structure

PDB	4IQW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target. Costi, R., Cuzzucoli Crucitti, G., Pescatori, L., Messore, A., Scipione, L., Tortorella, S., Amoroso, A., Crespan, E., Campiglia, P., Maresca, B., Porta, A., Granata, I., Novellino, E., Gouge, J., Delarue, M., Maga, G., Di Santo, R. J.Med.Chem.