CATH Domain 4iirA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Serine/threonine-protein kinase PRP4 homolog

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt Q13523

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q13523

PRP4B_HUMAN

Homo sapiens

Serine/threonine-protein kinase PRP4 homolog

PDB Structure

PDB	4IIR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches. Gao, Q., Mechin, I., Kothari, N., Guo, Z., Deng, G., Haas, K., McManus, J., Hoffmann, D., Wang, A., Wiederschain, D., Rocnik, J., Czechtizky, W., Chen, X., McLean, L., Arlt, H., Harper, D., Liu, F., Majid, T., Patel, V., Lengauer, C., Garcia-Echeverria, C., Zhang, B., Cheng, H., Dorsch, M., Huang, S.M. J.Biol.Chem.