CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.20 | Alpha-Beta Barrel | |
3.20.20 | TIM Barrel | |
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
Superfamily | Aldolase class I |
Functional Family | Dihydroorotate dehydrogenase (quinone), mitochondrial |
Enzyme Information
1.3.5.2 |
Dihydroorotate dehydrogenase (quinone).
based on mapping to UniProt Q02127
(S)-dihydroorotate + a quinone = orotate + a quinol.
-!- This Class 2 dihydroorotate dehydrogenase enzyme contains FMN. -!- The enzyme is found in eukaryotes in the mitochondrial membrane, in cyanobacteria, and in some Gram-negative and Gram-positive bacteria associated with the cytoplasmic membrane. -!- The reaction is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides. -!- The best quinone electron acceptors for the enzyme from bovine liver are ubiquinone-6 and ubiquinone-7, although simple quinones, such as benzoquinone, can also act as acceptor at lower rates. -!- Methyl-, ethyl-, tert-butyl and benzyl-(S)-dihydroorotates are also substrates, but methyl esters of (S)-1-methyl and (S)-3-methyl and (S)-1,3-dimethyldihydroorotates are not. -!- Class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1), NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor. -!- Formerly EC 1.3.99.11.
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UniProtKB Entries (1)
Q02127 |
PYRD_HUMAN
Homo sapiens
Dihydroorotate dehydrogenase (quinone), mitochondrial
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PDB Structure
PDB | 4IGH |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
SAR Based Optimization of a 4-Quinoline Carboxylic Acid Analog with Potent Anti-Viral Activity.
ACS MED.CHEM.LETT.
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