1 keywords

CATH Domain 4ifcA02

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.510 Transferase(Phosphotransferase); domain 1
Homologous Superfamily 1.10.510.10 Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Serine/threonine-protein kinase PRP4 homolog

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q13523
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q13523
PRP4B_HUMAN
Homo sapiens
Serine/threonine-protein kinase PRP4 homolog

PDB Structure

PDB 4IFC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches.
Gao, Q., Mechin, I., Kothari, N., Guo, Z., Deng, G., Haas, K., McManus, J., Hoffmann, D., Wang, A., Wiederschain, D., Rocnik, J., Czechtizky, W., Chen, X., McLean, L., Arlt, H., Harper, D., Liu, F., Majid, T., Patel, V., Lengauer, C., Garcia-Echeverria, C., Zhang, B., Cheng, H., Dorsch, M., Huang, S.M.
J.Biol.Chem.