CATH Classification

Domain Context

CATH Clusters

Superfamily Gingipain r; domain 1
Functional Family Gingipain R2

Enzyme Information

3.4.22.37
Gingipain R.
based on mapping to UniProt P95493
Hydrolysis of proteins and small molecule substrates, with a preference for Arg in P1.
-!- Strongly activated by glycine and stabilized by calcium. -!- Belongs to peptidase family C25.

UniProtKB Entries (1)

P95493
CPG2_PORGI
Porphyromonas gingivalis W83
Gingipain R2

PDB Structure

PDB 4IEF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Porphyromonas gingivalis Virulence Factor Gingipain RgpB Shows a Unique Zymogenic Mechanism for Cysteine Peptidases.
de Diego, I., Veillard, F.T., Guevara, T., Potempa, B., Sztukowska, M., Potempa, J., Gomis-Ruth, F.X.
J.Biol.Chem.