CATH Classification

Domain Context

CATH Clusters

Superfamily 3.90.320.10
Functional Family

Enzyme Information

3.1.12.1
5' to 3' exodeoxyribonuclease (nucleoside 3'-phosphate-forming).
based on mapping to UniProt Q97TX9
Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 3'-phosphates.
-!- Preference for single-stranded DNA.

UniProtKB Entries (1)

Q97TX9
CAS4_SACS2
Saccharolobus solfataricus P2
CRISPR-associated exonuclease Cas4

PDB Structure

PDB 4IC1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Toroidal structure and DNA cleavage by the CRISPR-associated [4Fe-4S] cluster containing Cas4 nuclease SSO0001 from Sulfolobus solfataricus.
Lemak, S., Beloglazova, N., Nocek, B., Skarina, T., Flick, R., Brown, G., Popovic, A., Joachimiak, A., Savchenko, A., Yakunin, A.F.
J.Am.Chem.Soc.
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