CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.630 | Cytochrome p450 | |
1.10.630.10 | Cytochrome P450 |
Domain Context
CATH Clusters
Superfamily | Cytochrome P450 |
Functional Family | Cytochrome P450 1A1 |
Enzyme Information
1.14.14.- |
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen.
based on mapping to UniProt P04798
|
4.2.1.152 |
Hydroperoxy icosatetraenoate dehydratase.
based on mapping to UniProt P04798
A hydroperoxy icosatetraenoate = an oxoicosatetraenoate + H(2)O.
-!- The mammalian enzymes accept a range of hydroperoxy icosatetraenoates (HPETE). -!- The human enzyme has highest activity with (12R)-HPETE, followed by (12S)-HPETE and (15R)-HPETE with much lower efficiency. -!- The murine enzyme has highest activity with (8R)-HPETE followed by (8S)-HPETE. All HPETE isoforms are converted to the corresponding oxoicosatetraenoate forms (KETE). -!- The enzymes also catalyze the reaction of EC 5.4.4.7.
|
UniProtKB Entries (1)
P04798 |
CP1A1_HUMAN
Homo sapiens
Cytochrome P450 1A1
|
PDB Structure
PDB | 4I8V |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Human Cytochrome P450 1A1 Structure and Utility in Understanding Drug and Xenobiotic Metabolism.
J.Biol.Chem.
|