CATH Domain 4i15A00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1300	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
	1.10.1300.10	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Domain Context

CATH Clusters

Superfamily	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family	Phosphodiesterase

Enzyme Information

UniProtKB Entries (1)

Q8WQX9_9TRYP

Trypanosoma brucei

Phosphodiesterase

PDB Structure

PDB	4I15
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Novel Trypanosoma brucei Phosphodiesterase B1 Inhibitors by Virtual Screening against the Unliganded TbrPDEB1 Crystal Structure. Jansen, C., Wang, H., Kooistra, A.J., de Graaf, C., Orrling, K.M., Tenor, H., Seebeck, T., Bailey, D., de Esch, I.J., Ke, H., Leurs, R. J.Med.Chem.