CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.1380 | Pyruvate Kinase; Chain: A, domain 1 |
|
3.40.1380.20 | Pyruvate kinase, C-terminal domain |
Domain Context
CATH Clusters
| Superfamily | Pyruvate kinase, C-terminal domain |
| Functional Family |
Enzyme Information
| 2.7.1.40 |
Pyruvate kinase.
based on mapping to UniProt P30615
ATP + pyruvate = ADP + phosphoenolpyruvate.
-!- UTP, GTP, CTP, ITP and dATP can also act as donors. -!- Also phosphorylates hydroxylamine and fluoride in the presence of CO(2).
|
UniProtKB Entries (1)
| P30615 |
KPYK1_TRYBB
Trypanosoma brucei brucei
Pyruvate kinase 1
|
PDB Structure
| PDB | 4HYW |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
`In crystallo' substrate binding triggers major domain movements and reveals magnesium as a co-activator of Trypanosoma brucei pyruvate kinase.
Acta Crystallogr.,Sect.D
|
