CATH Domain 4hymA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.230	Ribosomal Protein S5; domain 2
	3.30.230.10

Domain Context

CATH Clusters

Superfamily	3.30.230.10
Functional Family

Enzyme Information

5.6.2.3

DNA topoisomerase (ATP-hydrolyzing).

based on mapping to UniProt A0A0J9WZF0

ATP-dependent breakage, passage and rejoining of double-stranded DNA.

-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.

UniProtKB Entries (1)

A0A0J9WZF0

PARE_FRATH

Francisella tularensis subsp. holarctica LVS

DNA topoisomerase 4 subunit B

PDB Structure

PDB	4HYM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. Tari, L.W., Trzoss, M., Bensen, D.C., Li, X., Chen, Z., Lam, T., Zhang, J., Creighton, C.J., Cunningham, M.L., Kwan, B., Stidham, M., Shaw, K.J., Lightstone, F.C., Wong, S.E., Nguyen, T.B., Nix, J., Finn, J. Bioorg.Med.Chem.Lett.