CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.30 | 2-Layer Sandwich |
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3.30.565 | Heat Shock Protein 90 |
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3.30.565.10 | Histidine kinase-like ATPase, C-terminal domain |
Domain Context
CATH Clusters
Superfamily | Histidine kinase-like ATPase, C-terminal domain |
Functional Family | DNA gyrase subunit B |
Enzyme Information
5.6.2.3 |
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt A0A0J9WZF0
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.
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UniProtKB Entries (1)
A0A0J9WZF0 |
PARE_FRATH
Francisella tularensis subsp. holarctica LVS
DNA topoisomerase 4 subunit B
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PDB Structure
PDB | 4HXZ |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Bioorg.Med.Chem.Lett.
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