CATH Domain 4hvbA04

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1010	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4
	3.30.1010.10	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4

Domain Context

CATH Clusters

Superfamily	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4
Functional Family	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma

Enzyme Information

2.7.1.153	Phosphatidylinositol-4,5-bisphosphate 3-kinase. based on mapping to UniProt P48736 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate. -!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.
2.7.11.1	Non-specific serine/threonine protein kinase. based on mapping to UniProt P48736 ATP + a protein = ADP + a phosphoprotein. -!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

PK3CG_HUMAN

Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

PDB Structure

PDB	4HVB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design. Cheng, H., Li, C., Bailey, S., Baxi, S.M., Goulet, L., Guo, L., Hoffman, J., Jiang, Y., Johnson, T.O., Johnson, T.W., Knighton, D.R., Li, J., Liu, K.K., Liu, Z., Marx, M.A., Walls, M., Wells, P.A., Yin, M.J., Zhu, J., Zientek, M. ACS Med Chem Lett