CATH Domain 4huoX02

CATH Classification

Level	CATH Code	Description
	4	Few Secondary Structures
	4.10	Irregular
	4.10.470	Ricin (A Subunit), domain 2
	4.10.470.10	Ricin (A Subunit), domain 2

Domain Context

CATH Clusters

Superfamily	Ricin (A Subunit), domain 2
Functional Family	Ricin

Enzyme Information

3.2.2.22

rRNA N-glycosylase.

based on mapping to UniProt P02879

Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.

-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P02879

RICI_RICCO

Ricinus communis

Ricin

PDB Structure

PDB	4HUO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Peptide-conjugated pterins as inhibitors of ricin toxin A. Saito, R., Pruet, J.M., Manzano, L.A., Jasheway, K., Monzingo, A.F., Wiget, P.A., Kamat, I., Anslyn, E.V., Robertus, J.D. J.Med.Chem.