CATH Classification

Domain Context

CATH Clusters

Superfamily EAL domain
Functional Family Cyclic di-GMP phosphodiesterase yahA

Enzyme Information

3.1.4.52
Cyclic-guanylate-specific phosphodiesterase.
based on mapping to UniProt P76129
Cyclic di-3',5'-guanylate + H(2)O = 5'-phosphoguanylyl(3'->5')guanosine.
-!- Inhibited by Ca(2+) and Zn(2+). -!- Linearizes cyclic di-3',5'-guanylate, the product of EC 2.7.7.65 and an allosteric activator of EC 2.4.1.12 rendering it inactive. -!- It is the balance between these two enzymes that determines the cellular level of cyclic di-3',5'-guanylate.

UniProtKB Entries (1)

P76129
DOSP_ECOLI
Escherichia coli K-12
Oxygen sensor protein DosP

PDB Structure

PDB 4HU3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of the catalytic EAL domain of the Escherichia coli direct oxygen sensor.
Tarnawski, M., Barends, T.R., Hartmann, E., Schlichting, I.
Acta Crystallogr.,Sect.D