CATH Domain 4htxA00

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1300	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
	1.10.1300.10	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Superfamily	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family	Phosphodiesterase

3.1.4.17

3',5'-cyclic-nucleotide phosphodiesterase.

based on mapping to UniProt O00408

Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.

-!- Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.

PDE2A_HUMAN

Homo sapiens

CGMP-dependent 3',5'-cyclic phosphodiesterase

PDB	4HTX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	X-ray Crystal Structure of Phosphodiesterase 2 in Complex with a Highly Selective, Nanomolar Inhibitor Reveals a Binding-Induced Pocket Important for Selectivity. Zhu, J., Yang, Q., Dai, D., Huang, Q. J.Am.Chem.Soc.