CATH Domain 4hkqA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.10	HIV Type 1 Reverse Transcriptase; Chain A, domain 1
	3.10.10.10	HIV Type 1 Reverse Transcriptase, subunit A, domain 1

Domain Context

CATH Clusters

Superfamily	HIV Type 1 Reverse Transcriptase, subunit A, domain 1
Functional Family

Enzyme Information

2.7.7.7	DNA-directed DNA polymerase. based on mapping to UniProt A1Z651 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
2.7.7.49	RNA-directed DNA polymerase. based on mapping to UniProt A1Z651 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.
3.1.26.4	Ribonuclease H. based on mapping to UniProt A1Z651 Endonucleolytic cleavage to 5'-phosphomonoester. -!- Acts on RNA-DNA hybrids.
2.7.7.-	Nucleotidyltransferases. based on mapping to UniProt A1Z651
3.4.23.-	Aspartic endopeptidases. based on mapping to UniProt A1Z651
3.1.-.-	Acting on ester bonds. based on mapping to UniProt A1Z651

UniProtKB Entries (1)

POL_XMRV6

Xenotropic MuLV-related virus VP62

Gag-Pol polyprotein

PDB Structure

PDB	4HKQ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid Nowak, E., Potrzebowski, W., Konarev, P.V., Rausch, J.W., Bona, M.K., Svergun, D.I., Bujnicki, J.M., Le Grice, S.F., Nowotny, M. Nucleic Acids Res.