CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.50 | Rossmann fold |
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3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
Superfamily | NAD(P)-binding Rossmann-like Domain |
Functional Family | Corticosteroid 11-beta-dehydrogenase isozyme 1 |
Enzyme Information
1.1.1.146 |
11-beta-hydroxysteroid dehydrogenase.
based on mapping to UniProt P28845
An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH.
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UniProtKB Entries (1)
P28845 |
DHI1_HUMAN
Homo sapiens
Corticosteroid 11-beta-dehydrogenase isozyme 1
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PDB Structure
PDB | 4HFR |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Discovery of a Potent, Selective, and Orally Bioavailable Acidic 11 -Hydroxysteroid Dehydrogenase Type 1 (11 -HSD1) Inhibitor: Discovery of 2-[(3S)-1-[5-(Cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic Acid (AZD4017)
J.Med.Chem.
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