CATH Domain 4hfrA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Corticosteroid 11-beta-dehydrogenase isozyme 1

Enzyme Information

1.1.1.146

11-beta-hydroxysteroid dehydrogenase.

based on mapping to UniProt P28845

An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH.

UniProtKB Entries (1)

DHI1_HUMAN

Homo sapiens

Corticosteroid 11-beta-dehydrogenase isozyme 1

PDB Structure

PDB	4HFR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of a Potent, Selective, and Orally Bioavailable Acidic 11 -Hydroxysteroid Dehydrogenase Type 1 (11 -HSD1) Inhibitor: Discovery of 2-[(3S)-1-[5-(Cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic Acid (AZD4017) Scott, J.S., Bowker, S.S., Deschoolmeester, J., Gerhardt, S., Hargreaves, D., Kilgour, E., Lloyd, A., Mayers, R.M., McCoull, W., Newcombe, N.J., Ogg, D., Packer, M.J., Rees, A., Revill, J., Schofield, P., Selmi, N., Swales, J.G., Whittamore, P.R. J.Med.Chem.