CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Prostaglandin reductase 2 |
Enzyme Information
| 1.3.1.102 |
2-alkenal reductase (NADP(+)).
based on mapping to UniProt Q9SLN8
An n-alkanal + NADP(+) = an alk-2-enal + NADPH.
-!- Shows highest activity with 1-nitrocyclohexene but also has significant activity with 2-methylpentenal and trans-cinnamaldehyde. -!- Involved in the detoxification of alpha,beta-unsaturated aldehydes and ketones. -!- Has very low activity with NAD as reductant (cf. EC 1.3.1.74).
|
UniProtKB Entries (1)
| Q9SLN8 |
DBR_TOBAC
Nicotiana tabacum
2-alkenal reductase (NADP(+)-dependent)
|
PDB Structure
| PDB | 4HFM |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Biocatalytic Asymmetric Alkene Reduction: Crystal Structure and Characterization of a Double Bond Reductase fromNicotiana tabacum.
ACS Catal
|
