CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.180 | Quinone Oxidoreductase; Chain A, domain 1 |
|
3.90.180.10 | Medium-chain alcohol dehydrogenases, catalytic domain |
Domain Context
CATH Clusters
| Superfamily | Medium-chain alcohol dehydrogenases, catalytic domain |
| Functional Family | NADPH-dependent oxidoreductase 2-alkenal reductase |
Enzyme Information
| 1.3.1.102 |
2-alkenal reductase (NADP(+)).
based on mapping to UniProt Q9SLN8
An n-alkanal + NADP(+) = an alk-2-enal + NADPH.
-!- Shows highest activity with 1-nitrocyclohexene but also has significant activity with 2-methylpentenal and trans-cinnamaldehyde. -!- Involved in the detoxification of alpha,beta-unsaturated aldehydes and ketones. -!- Has very low activity with NAD as reductant (cf. EC 1.3.1.74).
|
UniProtKB Entries (1)
| Q9SLN8 |
DBR_TOBAC
Nicotiana tabacum
2-alkenal reductase (NADP(+)-dependent)
|
PDB Structure
| PDB | 4HFM |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Biocatalytic Asymmetric Alkene Reduction: Crystal Structure and Characterization of a Double Bond Reductase fromNicotiana tabacum.
ACS Catal
|
