CATH Domain 4hebA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.950	Maf protein
	3.90.950.10

Domain Context

CATH Clusters

Superfamily	3.90.950.10
Functional Family

Enzyme Information

3.6.1.9

Nucleotide diphosphatase.

based on mapping to UniProt Q02169

A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate.

-!- The enzyme preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates. -!- In vitro the enzyme also acts as a nucleotidohydrolase on ADP, NAD(+), NADP(+), FAD, and CoA. -!- Formerly EC 3.6.1.19.

UniProtKB Entries (1)

Q02169

NTPPA_BACSU

Bacillus subtilis subsp. subtilis str. 168

DTTP/UTP pyrophosphatase

PDB Structure

PDB	4HEB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Biochemical and structural studies of conserved maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides. Tchigvintsev, A., Tchigvintsev, D., Flick, R., Popovic, A., Dong, A., Xu, X., Brown, G., Lu, W., Wu, H., Cui, H., Dombrowski, L., Joo, J.C., Beloglazova, N., Min, J., Savchenko, A., Caudy, A.A., Rabinowitz, J.D., Murzin, A.G., Yakunin, A.F. Chem.Biol.