CATH Domain 4h1mA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	protein-tyrosine kinase 2-beta isoform X2

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt Q14289

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q14289

FAK2_HUMAN

Homo sapiens

Protein-tyrosine kinase 2-beta

PDB Structure

PDB	4H1M
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors. Bhattacharya, S.K., Aspnes, G.E., Bagley, S.W., Boehm, M., Brosius, A.D., Buckbinder, L., Chang, J.S., Dibrino, J., Eng, H., Frederick, K.S., Griffith, D.A., Griffor, M.C., Guimaraes, C.R., Guzman-Perez, A., Han, S., Kalgutkar, A.S., Klug-McLeod, J., Garcia-Irizarry, C., Li, J., Lippa, B., Price, D.A., Southers, J.A., Walker, D.P., Wei, L., Xiao, J., Zawistoski, M.P., Zhao, X. Bioorg.Med.Chem.Lett.