CATH Domain 4gx8A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.140	Metal-dependent hydrolases

Domain Context

CATH Clusters

Superfamily	Metal-dependent hydrolases
Functional Family	DNA polymerase III subunit alpha

Enzyme Information

2.7.7.7	DNA-directed DNA polymerase. based on mapping to UniProt P03007 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
2.7.7.7	DNA-directed DNA polymerase. based on mapping to UniProt P10443 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

DPO3A_ECOLI

Escherichia coli K-12

DNA polymerase III subunit alpha

PDB Structure

PDB	4GX8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Proofreading exonuclease on a tether: the complex between the E. coli DNA polymerase III subunits alpha, {varepsilon}, theta and beta reveals a highly flexible arrangement of the proofreading domain Ozawa, K., Horan, N.P., Robinson, A., Yagi, H., Hill, F.R., Jergic, S., Xu, Z.Q., Loscha, K.V., Li, N., Tehei, M., Oakley, A.J., Otting, G., Huber, T., Dixon, N.E. Nucleic Acids Res.