CATH Domain 4gv7A01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.142	Poly(ADP-ribose) Polymerase; domain 1
	1.20.142.10	Poly(ADP-ribose) polymerase, regulatory domain

Domain Context

CATH Clusters

Superfamily	Poly(ADP-ribose) polymerase, regulatory domain
Functional Family	Poly [ADP-ribose] polymerase

Enzyme Information

2.4.2.-

Pentosyltransferases.

based on mapping to UniProt P09874

2.4.2.30

NAD(+) ADP-ribosyltransferase.

based on mapping to UniProt P09874

NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.

-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.

UniProtKB Entries (1)

P09874

PARP1_HUMAN

Homo sapiens

Poly [ADP-ribose] polymerase 1

PDB Structure

PDB	4GV7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	PARP Inhibitor with Selectivity Toward ADP-Ribosyltransferase ARTD3/PARP3 Lindgren, A.E.G., Karlberg, T., Thorsell, A.G., Hesse, M., Spjut, S., Ekblad, T., Andersson, C.D., Pinto, A.F., Weigelt, J., Hottiger, M.O., Linusson, A., Elofsson, M., Schuler, H. Acs Chem.Biol.