CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.50 | Alpha/alpha barrel |
|
1.50.10 | Glycosyltransferase |
|
1.50.10.20 |
Domain Context
CATH Clusters
| Superfamily | 1.50.10.20 |
| Functional Family | Geranylgeranyl transferase type-2 subunit beta |
Enzyme Information
| 2.5.1.60 |
Protein geranylgeranyltransferase type II.
based on mapping to UniProt Q08603
Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl- protein + diphosphate.
-!- This enzyme, along with EC 2.5.1.58 and EC 2.5.1.59, constitutes the protein prenyltransferase family of enzymes. -!- Attaches geranylgeranyl groups to two C-terminal cysteines in Ras- related GTPases of a single family, the Rab family (Ypt/Sec4 in lower eukaryotes) that terminate in XXCC, XCXC and CCXX motifs. -!- Reaction is entirely dependent on the Rab substrate being bound to Rab escort protein (REP). -!- Post-translational modification with the geranylgeranyl moiety is essential for Rab GTPases to be able to control the processes of membrane docking and fusion.
|
UniProtKB Entries (1)
| Q08602 |
PGTA_RAT
Rattus norvegicus
Geranylgeranyl transferase type-2 subunit alpha
|
PDB Structure
| PDB | 4GTV |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Development of Selective, Potent RabGGTase Inhibitors
J.Med.Chem.
|
